Innovators in Psychedelics research & Development

Introduction

At Devil's Lettuce Test Labs, we are proud to be at the forefront of innovation in the testing and research of psychedelic mushrooms and mushroom derived products. As the conversation around psilocybin shifts from prohibition to potential, we are committed to helping pave the way for scientific discovery and therapeutic advancements.

With states across the U.S. beginning to legalize psilocybin for medical and research purposes, including Missouri’s recent bill enabling research into psychedelics for veterans, we recognize the urgency of ensuring these advancements are built on accurate and reliable data. Our testing services go beyond basic analysis: we provide the foundation for groundbreaking studies aimed at improving mental health and enhancing quality of life.

What we can test for

Psilocybin

Psilocybin is a naturally occurring psychoactive compound found in certain species of mushrooms, often referred to as "magic mushrooms." Once ingested, psilocybin is metabolized into psilocin, the active substance responsible for its mind-altering effects. Psilocybin interacts with serotonin receptors in the brain, particularly the 5-HT2A receptor, leading to changes in perception, mood, and cognition.

Psilocin

Psilocin is the active metabolite of psilocybin, responsible for the psychoactive effects experienced after consuming certain psychedelic mushrooms. When psilocybin is ingested, it is rapidly converted into psilocin in the body, which then interacts with serotonin receptors in the brain, particularly the 5-HT2A receptor. This interaction induces altered states of perception, mood, and cognition, often described as profound and introspective experiences.

Unlike psilocybin, psilocin is chemically unstable and degrades quickly when exposed to heat, light, or air, which is why dried mushrooms often contain higher levels of psilocybin than psilocin.

4-ACo-DMT

4-AcO-DMT (4-Acetoxy-N,N-dimethyltryptamine) is a synthetic psychedelic compound and a structural analog of psilocybin and psilocin. Sometimes referred to as "synthetic psilocybin," it is believed to act as a prodrug for psilocin, meaning it is metabolized in the body to produce similar psychoactive effects.

Like psilocin, 4-AcO-DMT primarily interacts with serotonin receptors, particularly the 5-HT2A receptor, resulting in altered perceptions, enhanced introspection, and a heightened sense of connection. Users often describe its effects as comparable to those of psilocybin mushrooms, though some report it feels smoother or more introspective.

Though less studied than psilocybin, 4-AcO-DMT is of interest in research for its potential therapeutic applications in treating mental health conditions like depression, anxiety, and PTSD. Its stability and ease of synthesis make it a valuable tool for exploring the pharmacology of psychedelics and their impact on consciousness. While it remains a controlled substance in many jurisdictions, it holds promise in expanding the understanding of psychedelic-assisted therapies.

Total Tryptamines

Measuring total tryptamines provides a comprehensive overview of a sample's psychoactive potential, making it a critical metric for research, therapeutic applications, and product standardization. This metric is particularly useful in assessing the potency and efficacy of psychedelic mushroom species or products, ensuring consistency and safety in both personal and clinical use.

Understanding total tryptamine content helps researchers and producers align their work with the growing demand for precision in psychedelic therapies, contributing to safer practices and deeper insights into the therapeutic potential of these compounds.